Senior Director, Patient Team Operations & Chief of Staff to the Chief Patient Officer

Stoke Therapeutics (Nasdaq: STOK), is a biotechnology company dedicated to restoring protein expression by harnessing the body’s potential with RNA medicine. Using Stoke’s proprietary TANGO (Targeted Augmentation of Nuclear Gene Output) approach, Stoke is developing antisense oligonucleotides (ASOs) to selectively restore naturally-occurring protein levels. Stoke’s first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study. Stoke’s initial focus are diseases of the central nervous system and the eye that are caused by a loss of ~50% of normal protein levels (haploinsufficiency). Proof of concept has been demonstrated in other organs, tissues, and systems, supporting broad potential for Stoke’s proprietary approach. Stoke is headquartered in Bedford, Massachusetts. For more information, visit https://www.stoketherapeutics.com/

The Senior Director, Patient Team Operations & Chief of Staff to the Chief Patient Officer (CPO) serves as a strategic and operational leader supporting the execution of enterprise patient strategy across Commercial, Medical Affairs and Manufacturing functions. This individual acts as a trusted advisor and operational partner to the CPO, driving cross-functional alignment, governance, execution excellence, and organizational effectiveness.

The role operates at the intersection of strategy and execution, partnering closely with Manufacturing, Medical Affairs, Market Access, Patient Services, Marketing, Regulatory, Clinical Development, Legal/Compliance, and Program Team leadership. The Senior Director will serve as a key liaison between the Patient Organization and cross-functional program teams to ensure integrated planning, decision-making, and operational follow-through across development and commercialization activities.

This position requires a highly collaborative leader with strong biotech/pharmaceutical experience, exceptional communication and organizational skills, and the ability to navigate complex, matrixed environments.

Serve as a strategic thought partner and operational extension of the Chief Patient Officer

Support development and execution of organizational priorities across Commercial and Medical Affairs

Drive annual strategic planning processes, goal setting, organizational priorities, and execution tracking

Prepare executive-level materials for Board meetings, leadership reviews, investor interactions, and governance forums

Identify organizational risks, gaps, and operational bottlenecks and proactively develop mitigation plans

Represent the Patient Organization within cross-functional program teams and governance structures

Ensure alignment between Commercial, Medical Affairs, Clinical, Regulatory, Market Access, and Patient Services strategies

Facilitate communication and decision-making across functions to support development-stage and/or launch-stage assets

Coordinate integrated launch readiness activities and milestone tracking where applicable

Drive accountability for deliverables, timelines, and cross-functional commitments

Lead operating cadence for the organization, including leadership meetings, governance reviews, strategic offsites, and business reviews

Establish and optimize processes, workflows, dashboards, and KPIs to improve organizational effectiveness

Manage prioritization and execution against key organizational initiatives.

Partner with Finance and functional leaders on budgeting, resource planning, headcount tracking, and vendor oversight

Support change management and organizational scaling initiatives as the company evolves

Drive internal communications on behalf of the Chief Patient Officer, ensuring consistent messaging and organizational alignment

Build strong relationships across senior leadership and act as a connector between functions

Support external engagement preparation for medical congresses, advisory boards, and other patient team activities as needed

Foster a culture of collaboration, accountability, and patient-centricity

Required

Bachelor’s degree required; advanced degree (MBA, MPH, PharmD, PhD, or equivalent) preferred

10+ years of experience in biotechnology, pharmaceuticals, or healthcare.

Significant experience within Commercial, Medical Affairs, Program Management, Operations, or Strategic Planning functions

Demonstrated success operating within highly matrixed, cross-functional organizations

Strong understanding of drug development and commercialization processes.

Experience supporting executive-level leaders and driving enterprise initiatives.

Exceptional project management, organizational, and operational execution skills

Excellent written, verbal, and executive communication capabilities

Experience participating in program team governance structures

Proven ability to influence without direct authority

Preferred

Rare disease and/or specialty biotech experience

Launch or pre-launch experience

Familiarity with compliance considerations across Commercial and Medical Affairs interactions

Prior consulting, strategy, or business operations experience

Critical Competencies

Strategic thinking with strong operational execution

Executive presence and judgment

Cross-functional leadership and influence

Organizational agility and prioritization

Program and stakeholder management

Communication and facilitation skills

Problem-solving and decision-making

Ability to thrive in fast-paced, evolving environments

Stoke is located in Bedford, MA, and will be moving to a new location in Waltham, MA by the end of 2026. This position is a hybrid position currently based in Bedford and will later be based in Waltham.

This position will require approximately 30% travel.

At Stoke Therapeutics, we are committed to offering a comprehensive, competitive and thoughtfully designed total rewards program.

The anticipated salary range for this role is $269,000 - $299,000. The final offer will be determined based on a variety of factors, including role scope, experience and qualifications, education, market benchmarks, internal equity, and geographic location. In addition to base salary, Stoke offers an annual bonus and equity participation.

Our benefits package includes medical, dental and vision insurance; life, long- and short-term disability insurance; paid parental leave; a 401K plan with company match, unlimited vacation time, tuition assistance and participation in our Employee Stock Purchase Program (ESPP).

At Stoke, we believe that innovation, the ability to successfully advance our ground-breaking science and having fun as a team are enhanced by being together in person, at least periodically. We allow for flexibility in work arrangements that balance individual’s needs and preferences with the needs of our business and our desire to foster a culture of collaboration and innovation.

Our values guide our work to deliver meaningful medicines for people who need them. We are committed to being true to ourselves, to our colleagues, and to the people with severe diseases who are counting on us. We embrace diversity within a unique culture that is defined by our values. Our employee-led Diversity, Inclusion, and Belonging (DIB) Committee underscores the importance of DIB to who we are and what we do.

Interested candidates: Please visit Stoke’s website to learn more and apply directly to the position listed on our Career Center:

https://www.stoketherapeutics.com/careers/

For more information, visit https://www.stoketherapeutics.com/.

All applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, physical or mental disability or protected veteran status.

Stoke participates in E-Verify.