Research Associate I/II – Clinical Pathology/IHC Biomarker Development

Thanks for visiting our Career Page. Please review our open positions and apply to the positions that match your qualifications.Research Associate I/II – Clinical Pathology/IHC Biomarker DevelopmentRedmond, WAFull TimeClinical Pathology/IHC Biomarker DevelopmentMid LevelShareSystImmune is a leading and well-funded clinical-stage biopharmaceutical company located in Redmond, WA and Princeton, NJ.

It specializes in developing innovative cancer treatments using its established drug development platforms, focusing on bi-specific, multi-specific antibodies, and antibody-drug conjugates (ADCs). SystImmune has multiple assets in various stages of clinical trials for solid tumor and hematologic indications.

Alongside ongoing clinical trials. SystImmune has a robust preclinical pipeline of potential cancer therapeutics in the discover and IND-enabling stages, representing cutting-edge biologics development.

We offer an opportunity for you to learn and grow while making significant contributions to the company's success.We are seeking a highly organized and detail-orientedResearch Associate I/IIto support the development, optimization, and validation of immunohistochemistry (IHC) assays. This role will contribute to early-stage biomarker in support of clinical trial programs.The ideal candidate will have2–3 years of hands-on industry experiencein histology, IHC, or a regulated laboratory environment (e.g., CLIA/CAP, GLP).

This is abench-focused positionrequiring close collaboration with scientists, pathologists, and cross-functional project teams.Key ResponsibilitiesHistologyPerform tissue sectioning of FFPE blocks.Route and support H&E staining workflows.IHC Assay ExecutionPerform routine IHC staining on FFPE tissue specimens using automated platforms (e.g., Ventana, Leica).Conduct antibody titrations, protocol optimization, slide preparation, and quality control checks.Assist in generating feasibility, optimization, and analytical validation data for emerging CDx assays.Experience withAkoya PhenoImagerHT platforms is preferred.Sample & Workflow SupportManage tissue samples and associated documentation.Prepare tissue sections, including slide cutting, baking, antigen retrieval, and reagent preparation.Maintain sample integrity, traceability, and documentation in compliance with quality system requirements.Support tissue handling workflows (blocks, slides, labeling, storage) within GLP or CLIA/CAP environments.Data Collection & DocumentationAccurately record experimental data in ELN and/or LIMS systems.Capture high-quality slide images and perform basic image analysis.Assist with slide scoring preparation and data summaries.Summarize experimental findings for internal meetings and assay development reviews.Instrument & Laboratory MaintenanceOperate, calibrate, and troubleshoot automated IHC staining platforms and related laboratory equipment.Perform routine instrument maintenance and maintain equipment logs per laboratory quality systems.Monitor and manage inventory of reagents, antibodies, controls, and consumables.Cross-functional SupportCollaborate with scientists, pathologists, QA, and clinical development teams on assay transfer, optimization, and validation activities.Support preparation of study materials, controlled documents, and protocol execution for validation studies.QualificationsRequiredBS or MS in Biology, Molecular Biology, Pathology, Biomedical Sciences, or a related field.1–3 years of hands-on experiencein histology and/or IHC assay execution within a research or regulated diagnostic laboratory.Experience handling FFPE tissues and operating automated IHC staining platforms.Strong attention to detail with excellent documentation and record-keeping practices.Ability to follow SOPs and work effectively in CLIA-, GxP-, or ISO-regulated environments.PreferredExperience supporting IHC assay optimization and/or analytical validation studies.Exposure toAkoya platformsandmultiplex immunofluorescenceprojects.Experience with digital pathology, slide scanning, or image analysis tools.Knowledge of antibody characterization and tissue-based biomarker assay development.Compensation and Benefits:The expected base salary range for this position is $60,000 - $80,000 annually. Actual compensation will be based on a variety of factors, including but not limited to a candidate’s qualifications, experience, and skills.While most offers typically fall within thelow to mid-pointof the range, we may extend an offer toward the higher end for exceptional candidates whose background and expertise exceeds the requirements of the role.SystImmune is a leading and well-funded biotech company with a bright future.

We offer an opportunity for you to learn and grow while making significant contributions to the company’s success. SystImmune offers a comprehensive benefits package including: 100% paid employee premiums for medical/dental/vision, also STD, LTD, a 401(k) plan with a 50% company match of up to 3% and a vesting schedule of only 5 years, 15 PTO days per year, sick leave, plus 11 paid holidays and MORE.We offer an opportunity for you to learn and grow while making significant contributions to the company’s success.SystImmune