Scientist-Sr. Scientist - Antibody Analytical Characterization Therapeutics Berkeley, CA

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Scientist-Sr. Scientist - Antibody Analytical Characterization

Berkeley, CA

Full Time

Therapeutics

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Scientist / Senior Scientist – Antibody Analytical Characterization

Prellis Biologics is advancing next-generation antibody therapeutics by integrating machine learning, scalable biology, and proprietary 3D-printed human lymph node organoids. We are expanding our platform into complex antibody modalities to develop innovative biologic medicines, with programs spanning

obesity, inflammation and immunology (I&I), and oncology

.

We are seeking a highly motivated

Scientist or Senior Scientist

with a strong background in

therapeutic antibody characterization

to join our therapeutics team. The successful candidate will contribute to the analytical assessment of

monoclonal antibodies, bispecifics, and Fc-fusion proteins

, supporting drug development through detailed

biophysical and biochemical characterization

.

Key

Perform comprehensive

analytical characterization

of therapeutic mAbs, bispecifics, and Fc-fusion proteins/antigens.

Conduct biophysical and stability assessments including

Tm, Tagg (Uncle), Size, AC-SINS, HIC, cIEF, aSEC, and BVP assays

.

Support

formulation, developability, and comparability studies

through analytical data generation and interpretation.

Prepare clear and concise reports summarizing experimental results.

Collaborate with

cross-functional teams

including process development, CMC, and Antibody Generation groups.

Ensure adherence to

laboratory safety, quality, and documentation standards

.

MS or PhD

in Biochemistry, Chemistry, Molecular Biology, or a related field.

2–3 years of industry experience

with characterization of therapeutic antibodies, bispecifics, or Fc-fusion proteins.

Strong hands-on experience with

Tm, Tagg (Uncle), Size, AC-SINS, HIC, cIEF, aSEC, and BVP assays

.

Demonstrated ability to work independently and collaboratively in a team environment.

Excellent

problem-solving, organizational, and communication skills

.

Experience in

antibody developability, stability profiling, or comparability studies

.

LC-MS-based antibody characterization

(intact, subunit, peptide mapping) for detailed structural analysis.

Knowledge of

regulatory expectations

for therapeutic biologics characterization.

About Prellis Biologics

At Prellis we integrate human biology with machine learning. We aim to revolutionized drug discovery by harnessing the power of human immune system with tightly, integrated machine learning to develop next-generation antibody therapeutics with unparalleled speed, precision and safety. We are committed to empowering our pharmaceutical partners with access to the most promising fully human body candidate rapidly identified from the human immune repertoire, enabling them to bring life-changing treatments to patients faster than ever before.

Prellis Biologics is a pre-IPO company located in Berkeley CA with a team-oriented, inclusive, and family-friendly culture. Our growing pipeline target high unmet patient needs across therapeutics including metabolic, inflammation, and autoimmune disease. Prellis has raised funding from top investors, including Celesta, Khosla Ventures, SOSV, & Avidity Partners

What You Can Expect Of Us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive

benefits to our collaborative culture, we’ll support your journey every step of the way.

Actual salary will vary based on several factors including, but not limited to, relevant skills, experience, and

In addition to the base salary, Prellis offers compelling

benefits based on eligibility, comprising health and welfare plans for staff and eligible dependents, financial plans with opportunities to save toward retirement or other goals, work/life balance, and career development opportunities that may include:

A competitive employee

benefits package, including group medical, dental, and vision coverage, life and disability insurance, flexible spending accounts, and a 401(k) plan

Stock-based long-term incentives

Holiday package including a 1+ week winter shutdown

Flexible work models, including remote and hybrid working arrangements, where possible

Application Deadline

Prellis does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Equal Opportunity

Prellis Bio is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran, or disability status.

We believe diversity, equity, and inclusion need to be at the foundation of our culture. We work hard to bring together diverse teams — grounded in a wide range of expertise and life experiences — and work even harder to ensure those teams thrive in inclusive, growth-oriented environments supported by equitable company and team practices. All candidates can expect equitable treatment, respect, and fairness throughout the interview process.

Application deadline

Prellis does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Prellis Bio is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.

We believe diversity, equity, and inclusion need to be at the foundation of our culture. We work hard to bring together diverse teams–grounded in a wide range of expertise and life experiences–and work even harder to ensure those teams thrive in inclusive, growth-oriented environments supported by equitable company and team practices. All candidates can expect equitable treatment, respect, and fairness throughout the interview process.

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$147,000 - $191,000 per year

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