Principal Scientist, Drug Product Development

Parabilis Medicines is a clinical-stage biopharmaceutical company dedicated to creating extraordinary medicines for patients with serious diseases by unlocking biologically important targets long considered undruggable. The company has pioneered a new class of alpha-helical peptides – Helicons™ – capable of modulating intracellular proteins that have historically been beyond the reach of conventional medicines. The company’s lead investigational medicine, zolucatetide, is the first and only direct inhibitor of the β-catenin:TCF interaction, a central node in the Wnt/β-catenin pathway that has eluded drug developers for decades. Zolucatetide is being evaluated in the clinic across multiple Wnt/β-catenin-driven diseases, including desmoid tumors, familial adenomatous polyposis (FAP) and a range of other solid tumor indications. Beyond zolucatetide, Parabilis is advancing additional Helicon-based programs focused on other challenging targets where we believe our medicines could have life-altering impact. For more information, visit www.parabilismed.com or follow us on LinkedIn.

We are seeking a Principal Scientist with deep expertise in drug product formulation development for peptide therapeutics to play a critical role in advancing Parabilis Med’s pipeline and delivery platforms from early development through clinical/commercial stages.

This position will lead formulation strategies across multiple delivery modalities (parenteral, oral, and advanced delivery systems), integrate closely with discovery, DMPK, analytical, and CMC teams, and help establish Parabilis Med’s drug product development capabilities.

Lead formulation development for peptide therapeutics across parenteral (SC/IV/IM), oral, and advanced delivery systems (e.g., nanoparticles, depot formulations)

Design and optimize dosage forms including injectables, tablets, capsules, and enabling delivery technologies

Evaluate and implement high concentration peptide formulation, incorporating sustained release, absorption enhancement, and stabilization strategies

Design and interpret biorelevant in vitro and in vivo studies to support PK/PD and candidate selection

Contribute to CMC development from early feasibility through IND-enabling and clinical stages

Support technology transfer, scale-up, and external manufacturing (CRO/CDMO) activities

Collaborate cross-functionally with DMPK, biology, analytical, and regulatory teams

Provide technical leadership and mentorship within Pharmaceutical Sciences.

PhD in Pharmaceutics, Pharmaceutical Sciences, Chemical Engineering, Chemistry, or related field

8-10+ years of industry experience in drug product development for peptides and/or biologics

Demonstrated expertise in multiple formulation modalities, including parenteral formulations (SC/IV/IM), and oral dosage forms

Experience in advanced delivery systems (e.g., nanoparticles, depot formulations) is a plus.

Strong understanding of biopharmaceutics, stability, release/absorption and in vitro–in vivo translation

Experience contributing to IND/CTA-enabling CMC activities

Experience with late-stage or commercial formulations is highly desirable

Experience working with and managing CRO/CDMO partners

Strong scientific judgment, problem-solving skills, and communication

Parabilis Medicines is a team of passionate pioneers who are trailblazing the future of precision medicine with the aim of making a meaningful difference in the lives of patients. The company is committed to promoting an inspiring and flourishing working environment for all employees across the business, in all departments, and driving innovation for patient benefit.

Growth-Minded. We’re inventing a new class of medicines—one applicable to therapeutic targets that have been dreamt about, but always considered impossible to drug. Our work requires us to be curious, humble and adaptable.

In(ter)dependent. We are fiercely independent as a leader in defying the limitations of current therapeutic modalities, and interdependent as a team as we work collaboratively to shift drug discovery paradigms and provide patients with better treatment options.

Patient-focused. We are deeply focused on patient outcomes, and all energy in the company is focused on science as it translates to patient impact.

All-In. We’re All-In on solving some of the hardest scientific challenges and delivering one of the most effective new classes of drugs in history.

The base salary range for this position is $165,000-$200,000 per year, depending on experience, qualifications, and internal practices. Parabilis’s total compensation package also includes an annual target bonus, equity, and a comprehensive suite of competitive benefits designed to support our employees’ overall well-being.

As an equal opportunity employer, Parabilis Medicines values an inclusive workplace and welcomes applicants of all backgrounds and experiences. All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.

30 Acorn Park Drive | Cambridge, MA 02140 | www.parabilismed.com