Manager/Sr. Manager, Human Resources

Avalyn aims to transform the treatment paradigm for pulmonary fibrosis and other serious, rare respiratory diseases. The company is advancing optimized inhaled formulations of established antifibrotic medicines designed to deliver drug directly to the lungs, enhance local efficacy, and reduce systemic side effects. Avalyn’s AP01 program is an optimized inhaled formulation of pirfenidone currently being evaluated in MIST, a global Phase 2b clinical trial in patients with progressive pulmonary fibrosis (PPF). AP01 has demonstrated encouraging safety and clinical activity across Phase 1b and an ongoing, multi-year open-label extension trial, with long-term data supporting the potential to preserve lung function while improving tolerability relative to historical oral pirfenidone. Avalyn’s AP02 program is an optimized inhaled formulation of nintedanib currently being evaluated in AURA, a global Phase 2 clinical trial in patients with idiopathic pulmonary fibrosis (IPF). Avalyn is also advancing AP03, an inhaled fixed-dose combination of pirfenidone and nintedanib, designed to deliver multiple antifibrotic mechanisms through a single lung-targeted platform. By leveraging its proprietary drug-device approach and deep expertise in rare respiratory disease development, Avalyn aims to establish a new standard of care in pulmonary fibrosis through inhaled, lung-targeted therapies. For more information, please visit avalynpharma.com and follow the company on LinkedIn.

As Avalyn Pharma advance from a pre-commercial company into the next phase of our growth, we are seeking an HR Manager or Sr. Manager who is eager to develop broad, cross-functional HR expertise rather than specialize narrowly in a single function.

This opportunity is ideal for an HR professional early-to-mid in their career who is naturally curious about the discipline and excited by variety. One day you may partner on full-cycle recruiting, another you may lead a compliance audit, build an intern program from the ground up, or improve the systems that support our People operations. This is intentionally a broad role designed to build expertise across the full employee lifecycle while working alongside a small, collaborative HR team committed to your development. This role will report into the VP, HR.

Partner with hiring managers and external recruiting partners to define hiring strategies, role requirements, success profiles, and interview processes

Contribute to sourcing strategy and help maintain strong candidate pipelines across clinical, regulatory, and G&A functions

Manage and continuously improve Greenhouse workflows, including coordination with external recruiting partners

Help ensure a candidate’s experience consistent with Avalyn's culture and standards

Support offer development and compensation alignment, with guidance from HR leadership as this skill set develops

Own Avalyn's summer intern program from design through execution

Partner with business leaders to identify meaningful project work and deliver a strong intern experience

Use this initiative as an opportunity to build program management and leadership capability

Own compliance tracking across federal, state, and multi-state employment law requirements

Lead leave of absence administration, including FMLA and MA PFML

Manage I-9 processing, background checks, and employment verifications

Take the lead on internal and external audits, including payroll, benefits, and worker classification, as a means of developing deep HR expertise

Maintain audit-ready records and partner with HR leadership on policy interpretation

Play a leading role in core lifecycle processes, including onboarding, offboarding, transfers, and employee data integrity

Support HRIS and systems administration, ensuring data accuracy across Greenhouse, ADP Workforce Now, Absorb, and related platforms

Identify process inefficiencies and implement scalable solutions, including checklists, templates, and documentation

Partner with payroll to ensure accurate, timely processing

A minimum of a Bachelor’s degree with 5–8+ years of progressive Human Resources experience, including exposure to talent acquisition, HR operations, or a combination of both

Demonstrated curiosity and a desire to build expertise across multiple Human Resources disciplines

Comfort operating in a fast-paced, evolving environment with shifting priorities and expanding scope

Strong interpersonal, communication, and organizational skills, with a collaborative, team-oriented approach

Experience with an ATS (e.g., Greenhouse) and/or HRIS platform (e.g., ADP Workforce Now) preferred but not required; training will be provided

Experience in biotech, life sciences, or another high-growth industry

Exposure to compliance, leave administration, audit support, or other core HR operational functions

A demonstrated track record of building a program, process, or workflow from the ground up

Proposed pay range

$130,000—$178,000 USD