RESEARCH ASSOCIATE

Who We Are

BioMarin is a global biotechnology company that relentlessly pursues bold science to translate genetic discoveries into new medicines that advance the future of human health.

Since our founding in 1997, we have applied our scientific expertise in understanding the underlying causes of genetic conditions to create transformative medicines, using a number of treatment modalities.

Using our unparalleled expertise in genetics and molecular biology, we develop medicines for patients with significant unmet medical need. We enlist the best of the best – people with the right technical expertise and a relentless drive to solve real problems – and create an environment that empowers our teams to pursue bold, innovative science. With this distinctive approach to drug discovery, we’ve produced a diverse pipeline of commercial, clinical and preclinical candidates that have well-understood biology and provide an opportunity to be first-to-market or offer a substantial benefit over existing therapeutic options.

About Technical Operations

BioMarin’s Technical Operations group is responsible for creating our drugs for use in clinical trials and for scaling production of those drugs for the commercial market. These engineers, technicians, scientists and support staff build and maintain BioMarin’s cutting-edge manufacturing processes and sites, provide quality assurance and quality control to ensure we meet regulatory standards, and procure the needed goods and services to support manufacturing and coordinating the worldwide movement of our drugs to patients.

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Research Associate

BioMarin is the world leader in delivering therapeutics that provide meaningful advances to patients who live with serious and life-threatening rare genetic diseases. We target diseases that lack effective therapies and affect relatively small numbers of patients, many of whom are children. These conditions are often inherited, difficult to diagnose, progressively debilitating, and have few, if any, treatment options. BioMarin will continue to focus on advancing therapies that are the first or best of their kind.

BioMarin’s Technical Operations group is responsible for creating our drugs for use in clinical trials and for scaling production of those drugs for the commercial market. The Analytical Sciences department, a part of Technical Development and Services (TDS) within Tech Ops (TOPS), supports all assay needs in Tech Ops. Our scientists and associates are experts in analytics of small molecules, oligosaccharides, peptides, complex glycosylated enzymes, and PEGylated proteins. We develop and qualify assays to follow the quality attributes of our products, support IND and BLA applications, assess the capability of our processes by analyzing in-process samples all the way from bioreactors through purification steps to the drug substance and develop release assays for transfer to Quality. We are also instrumental in time-critical analysis support to Manufacturing as needed. Come join our team and make a meaningful impact on patients’ lives.

JOB SUMMARY

The Analytical Sciences department at BioMarin Pharmaceutical Inc. is seeking a skilled Analytical Biochemist and/or Biologist at the Research Associate level to join a team focused on supporting gene therapy & enzyme replacement therapy. The successful candidate will be a self-motivated, independent and critical thinker who has experience of working in a multi-disciplinary and fast-paced environment, and solid communication skills. The candidate will execute a wide variety of analytical methods and assays for the characterization of therapeutic candidates in development with a particular focus on testing to support clinical and commercial process development teams.

RESPONSIBILITIES

Primary responsibility: Execute product testing to support Drug Substance and Drug Product process development teams

Perform non-routine testing of in-process samples, and final product samples of key projects for the TDS processing team

Conduct analytical tests using techniques such as HPLC, UPLC, CE, FTIR, and plate-based methods

Document all test results accurately and in compliance with Good Laboratory Practices (GLP) and company SOPs.

Collaborate with cross-functional teams including Drug Substance Technologies, Drug Product Device Technologies, Manufacturing, and Quality.

Provide concise and quantitative analysis of data and interpretation of experimental results.

Provide effective oral presentations at departmental meetings

Report progress to the manager on a weekly basis on each program

Write up experimental plans and results and share with collaborators and supervisor; present data proactively and regularly in group meetings.

Catalogue data/reports electronically in an accessible manner for inspections

EXPERIENCE

Required Skills:

Strong understanding of GMP, GLP, and regulatory standards

Familiar with protein chemistry/function and bioassays

Experienced in cell culture techniques and protein expression/activity readout methods

Excellent communication, collaboration and writing skills

Proven data analysis, interpretation and scientific communication skills

Proven flexibility and execution skills to deliver in a fast-paced, multi-tasking environment

Desired Skills:

Experience in method troubleshooting, qualification, and transfer

Knowledge of biopharmaceutical development is a plus

EDUCATION

Research Associate 1: Bachelors degree in biological sciences and at least 2 years of relevant experience, or 1 year experience with Masters.

Support the organisation’s commitment to environmental protection, injury prevention, and continual improvement of EHS management systems. Actively contribute to a safe and environmentally responsible workplace by identifying hazards, reporting incidents and participating in EHS initiatives and training

We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, sexual orientation,

national origin, disability status, protected veteran status, or any other characteristic protected by law.