About this role
Your Role
As a Principal Scientist (all genders) in the Structural Biology and Biophysics team, R&D Discovery, you will provide scientific leadership across interdisciplinary projects to elucidate structural mode of action and enable structure-based design with a focus on macromolecular complexes of antibodies, multispecifics, and molecular degraders. You will implement and broaden single-particle cryo-EM capabilities and drive experimental end-to-end strategies for structural enablement from protein and sample generation, data acquisition to structural model building. You will coordinate CRO and collaboration-partner activities for reagents and data generation and drive innovations in structural biology.
You clearly explain and communicate scientific findings and proposals to cross-functional teams and stakeholders to influence informed and fast decision-making. You will mentor and develop junior scientists in structural biology and drug discovery, contributing to a high-performing, collaborative culture.
Who You Are
- ✓PhD in Structural Biology or a related field with more than ten years of relevant experience (including biopharma/biotech) and a strong track record to design, execute and drive complex structural biology projects.
- ✓Deep expertise in high-resolution structure determination by cryo-EM (sample generation, data collection and processing, structure refinement with industry-standard software).
- ✓Experience working with antigen–antibody and protein degrader complexes, with a deep understanding of structure–function relationships.
- ✓Preferably experience in protein crystallography and biophysical methods (e.g. HDX-MS, SAXS; Refeyn, FIDA, DSF); cloud-based/HPC data management and processing; LINUX scripting; AI/ML-based prediction of biomolecular structures.
- ✓Effective collaborator and leader in multidisciplinary settings with excellent English communication; skilled in guiding and mentoring scientists, coordinating multi-site work, and managing CROs to balance project demands.
- ✓Proven ability to convey complex data clearly to drive decisions; strong publication history or impactful drug discovery contributions (oncology/immunology/neuroscience favored); excellent problem-solving and experience introducing relevant new technologies.
AT / Expert 3
HC-RD-XPS Structural Biology & Biophysics