Scientist II / Senior Scientist, ADME

Company Overview

Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted cancer therapies. We are advancing an innovative portfolio of therapeutics, supported by a leadership team with deep experience in the design, development, and commercialization of cutting-edge therapies, including antibody-drug conjugates. Our pipeline includes varegacestat, an investigational gamma secretase inhibitor for which an NDA has been accepted by the U.S.

FDA; IM-1021, a clinical-stage ROR1 ADC; IM-1617, a clinical-stage solid tumor ADC; and IM-3050, a clinical-stage FAP-targeted radioligand therapy. We are also advancing a broad portfolio of early-stage ADCs pursuing undisclosed solid tumor targets.

Position Overview

The Scientist II / Senior Scientist, ADME will contribute to the design and execution of nonclinical pharmacokinetics/PKPD/ADME strategies to support oncology drug candidates from discovery through development. This role will partner closely with cross-functional teams to deliver high-quality data that informs decision-making and regulatory submissions. Reporting to the Executive Director, Head of ADME, the Scientist II will work on multiple modalities, with a strong emphasis on ADC programs.

Responsibilities

• ✓Perform modeling and simulation, analyze PKPD and PK/TK data, and provide clear interpretation to inform program decisions.
• ✓Design and execute stage-appropriate PKPD and ADME studies to support candidate selection, clinical development, and regulatory submissions.
• ✓Collaborate with cross-functional teams to ensure integration of ADME considerations into program strategy and timelines.
• ✓Participate in Translational Sciences and Development team activities, contributing scientific expertise in ADME.
• ✓Represent the ADME function at internal and external meetings, in collaboration with senior scientists, communicating timelines, data, and implications effectively.
• ✓Maintain awareness of evolving best practices and regulatory expectations in ADME sciences.

Qualifications

• ✓PhD in a relevant discipline with 0–3 years of industry experience in ADC PKPD and ADME, or MS with 5+ years relevant industry experience.
• ✓Experience with ADCs required; additional experience with small molecules, monoclonal antibodies, or other modalities preferred.
• ✓Hands-on expertise in PKPD modeling, PK/TK analysis, and study design.
• ✓Knowledge of both non-regulated and regulated bioanalysis.

Knowledge and Skills

• ✓Strong problem-solving skills with the ability to manage multiple projects in a fast-paced environment.
• ✓Excellent communication skills, with the ability to present complex scientific data clearly to diverse audiences.

Collaborative approach with the ability to work across disciplines to achieve program goals.

Level and compensation will be commensurate with relevant experience.

Washington State Pay Range

$149,930—$203,961 USD

E/E/O

Immunome, Inc. is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

E-Verify

Immunome, Inc. is a participant in E-Verify. Please review the following notices: E-Verify Participation Poster | Right to Work Poster (English) | Right to Work Poster (Spanish).