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Krystal Biotech, Inc. · Life sciences

Research Associate, Upstream Process Development

Krystal Biotech, Inc. Posted Sep 4, 2026
Workplace
On-site / per employer
Posted
Sep 4, 2026

About this role

Thanks for visiting our Career Page. Please review and apply to our positions which match your qualifications.Krystal Biotech, a Pittsburgh-based company founded in 2016, has quickly emerged as a global leader in gene therapy. In May 2023, Krystal Bio received FDA approval for the first-ever redosable gene therapy, VYJUVEK™, for the treatment of Dystrophic Epidermolysis Bullosa.

Krystal continues to leverage their proprietary platform to develop new treatments throughout its clinical pipeline. Additionally, the company has developed innovative commercial- and clinical-stage manufacturing processes, deployed across two state-of-the-art GMP facilities.BenefitsWe make every effort to provide essential and desirable benefits that make each employee's life that much easier. In addition to benefits listed below, we also offer competitive compensation that rewards you for your contributions toward achieving company goals.

Benefits include:Equity CompensationMedical and Prescription Drug CoverageDental and Vision InsuranceShort and Long-Term Disability Insurance401(k) With Company Match401(k) Annual Student Loan Match ProgramPaid HolidaysPaid Time OffFlexible Spending Accounts (Health Care & Dependent Care)Health Savings AccountEmployee Assistance Program & Benefits Concierge AppAD&D and Life InsuranceWellness Rewards ProgramResearch Associate, Upstream Process DevelopmentPittsburgh, PAFull TimeProcess DevelopmentEntry LevelShareAbout Krystal Bio:At Krystal Biotech, we bring together the brightest and most eager minds to relentlessly pursue the discovery, development, manufacturing, and commercialization of genetic medicines to treat diseases with high unmet medical needs.Founded in 2016, Krystal is distinguished in three powerful ways: science and technology using our patented gene therapy platform, innovative manufacturing supported by our commercial scale facilities, and a unique commercialization model that focuses on the patient’s end-to-end experience.Krystal received U.S. FDA approval for the first and only redosable gene therapy treatment, VYJUVEK®, for the treatment of Dystrophic Epidermolysis Bullosa (DEB). Krystal continues to leverage our proprietary platform to rapidly advance a robust pipeline of investigational genetic medicines in respiratory, oncology, dermatology, and ophthalmology.Krystal is headquartered in Pittsburgh, PA, which is home to our two state-of-the-art CGMP manufacturing facilities with teams around the world and satellite offices in Switzerland, Germany, and Japan.

We are a company built and run by people who care, are fearless in the face of a challenge, love the work they do, and practice the highest level of scientific integrity. As we grow, we are seeking team members that embody these values.Position Summary:Krystal Biotech, Inc. is seeking a highly motivated and innovative Research Associate to support multidisciplinary efforts in Upstream Process Development.The Research Associate will support process development initiatives by conducting experiments related to the characterization, optimization, and scale-up of viral vector production. They will support the tech transfer of developed processes to the Manufacturing team.Primary Responsibilities:Set up and operate bench scale bioreactors under the guidance of senior staffPerform mammalian cell culture using aseptic techniquesPrepare buffers and media, maintain equipment, and order supplies to ensure the lab runs smoothlyProvide technical support in the lab through equipment maintenance and troubleshootingParticipate in study design and process development brainstorming sessionsDesign scientifically sound experiments and record data accurately in electronic lab notebooksAdhere to safety guidelines and maintain a clean and orderly lab environmentAnalyze experimental data and effectively communiate findings with manager and rest of process development teamInteract with cross-functional teams (manufacturing, MSAT, etc.) to identify and solve problems encountered during process scale-upRequirements and Preferred Qualifications:Bachelor’s Degree in Biomedical Engineering, Chemical Engineering, Bioengineering or a related scientific discipline.Some understanding in one or more of the following areas: aseptic technique, mammalian cell culture, bioreactor technology, cell biology, and/or virologyFamiliarity with bioreactor operation and upstream processing is a plusFamiliarity with lab automation or basic coding is a plusHigh capability of multitasking in a fast-paced team-oriented environmentExcellent oral and written communication skillsKrystal Biotech, Inc. is anEqual Employment Opportunity and Affirmative Action Employers.

Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender perception or identity, national origin, age, marital status, protected veteran status, or disability status. Headhunters and recruitment agencies may not submit resumes/CVs through this Web site or directly to managers.Krystal Biotech, Inc.does not accept unsolicited headhunter and agency resumes. Krystal Biotech, Inc.  will not pay fees to any third-party agency or company that does not have a signed agreement with Krystal Biotech, Inc.ShareApplyApply for this positionRequiredFirst NameLast NameEmail AddressPhoneAddressResumeWe've received your resume.

Clickhereto update it.Attach resumeorPaste resumeAttach resume as .pdf, .doc, .docx, .odt, .txt, or .rtf (limit 5MB) orPaste resumePaste your resume here orAttach resume fileCover LetterWhat's your citizenship / employment eligibility?No answerI am a U.S. Citizen/Permanent ResidentNon-citizen allowed to work for any employerNon-citizen allowed to work for current employerNon-citizen seeking work authorizationI am a Canadian Citizen/Permanent ResidentOtherDesired salaryEarliest start date?The following questions are entirely optional.To comply with government Equal Employment Opportunity and/or Affirmative Action reporting regulations, we are requesting (but NOT requiring) that you enter this personal data. This information will not be used in connection with any employment decisions, and will be used solely as permitted by state and federal law.

Your voluntary cooperation would be appreciated.Learn more.GenderDecline to answerFemaleMaleRace/EthnicityDecline to answerHispanic or LatinoWhite, not Hispanic or LatinoBlack or African-American, not Hispanic or LatinoAsian, not Hispanic or LatinoNative Hawaiian or Other Pacific Islander, not Hispanic or LatinoAmerican Indian or Alaskan Native, not Hispanic or LatinoTwo or More Races, not Hispanic or LatinoMENA (Middle Eastern and North African)Human Check*Submit Application

Originally posted by Krystal Biotech, Inc.. View original posting