Deciphera, a member of Ono Pharmaceutical Co., Ltd., is a biopharmaceutical company focused on discovering, developing, and commercializing important new medicines and providing hope to people living with cancer, neurologic and autoimmune disease. Deciphera is leveraging its proprietary switch-control kinase inhibitor platform and deep expertise in kinase biology to develop a broad portfolio of innovative medicines. In addition to advancing multiple product candidates from Deciphera’s platform in clinical studies, QINLOCK® (ripretinib) is Deciphera’s switch-control kinase inhibitor approved in many countries including the European Union and the United States for the treatment of adult patients with advanced gastrointestinal stromal tumor (GIST) who have received prior treatment with 3 or more kinase inhibitors, including imatinib.
ROMVIMZA® (vimseltinib) is a kinase inhibitor approved in the United States for adult patients with symptomatic tenosynovial giant cell tumor (TGCT) for which surgical resection will potentially cause worsening functional limitation or severe morbidity, and in the European Union for adult patients with TGCT associated with clinically relevant physical function deterioration and in whom surgical options have been exhausted or would induce unacceptable morbidity or disability.
The spirit of collaboration that has brought medications to life continues to guide how we operate, grow, and discover new breakthroughs. We cultivate an inclusive culture that values curiosity, creativity, and shared accountability—empowering individuals to challenge the unknown together.
Deciphera offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.
The Regional Business Director will prepare for the anticipated launch of tirabrutinib, a highly potent and selective Bruton tyrosine kinase (BTK) inhibitor being advanced for patients with relapsed or refractory primary central nervous system lymphoma (R/R PCNSL). PCNSL is a rare and aggressive extra-nodal non-Hodgkin lymphoma with significant unmet need, and tirabrutinib represents an important potential new treatment option for patients facing limited therapeutic choices.
The Regional Business Director will lead a regional sales team and play a critical role in shaping launch readiness by building regional business plans, developing team capabilities, and partnering closely with Market Access, Medical Affairs, Marketing, Commercial Operations, and other cross-functional stakeholders to prepare for a successful launch and support Deciphera’s efforts to bring tirabrutinib to patients in need.
Key Responsibilities
Commercial Strategy & Business Planning (25%)
Develop and execute regional business plans aligned with organizational strategy, including clear actions, timelines, and success metrics
Analyze market dynamics, customer segments, and business performance to inform strategy and decision-making. Identify customer needs and align organizational resources to effectively meet those needs
Provide strategic input to commercial planning, including feedback on tools, resources, and field execution strategies
Develop data-driven assessments of business performance and provide recommendations to optimize future outcomes
Sales Leadership & Execution Excellence (30%)
Lead team execution to achieve or exceed business objectives through effective prioritization, planning, and resource utilization
Ensure effective use of tools (e.g., CRM systems) to manage customer engagement, track progress, and optimize performance
Partner with cross-functional stakeholders to deliver a seamless and compliant customer experience
Optimize territory alignment, customer targeting, and field activities to maximize impact
Ensure completion of required administrative and compliance-related activities
Talent Leadership & Team Development (25%)
Lead and develop a high-performing sales team through coaching, feedback, and performance management
Establish clear performance expectations aligned with business goals and organizational values
Assess individual and team capabilities, identify gaps, and implement targeted development plans
Foster a culture of continuous learning, improvement, and accountability
Attract, develop, and retain top talent while building a strong leadership pipeline
Cross-Functional Leadership & Enterprise Collaboration (10%)
Partner effectively with internal stakeholders (e.g., Market Access, Marketing, Medical, Commercial Operations, Training) to drive aligned execution
Influence and contribute to broader commercial strategy and organizational initiatives
Share insights and best practices across teams to enhance overall business performance
Build strong, collaborative relationships across field and home office functions
Culture, Compliance & Operational Leadership (10%)
Promote a culture grounded in integrity, accountability, collaboration, and patient focus
Ensure all activities are conducted in compliance with company policies, industry standards, and regulatory requirements
Manage regional budgets and operational activities in alignment with business objectives
Lead with a strong ethical framework and reinforce expected behaviors across the team
Other duties and responsibilities as assigned
Required Qualifications
Bachelor’s degree in business, life sciences, or related discipline
12+ years of experience in the pharmaceutical or biotechnology industry including 3+ years front-line malignant hematology sales experience and 5+ years experience in malignant hematology or oncology sales leadership roles
Demonstrated experience recruiting, organizing, developing, and retaining a cohesive, high performing sales team
Proven track record of delivering results in competitive, complex environments
Strong ability to analyze data, generate insights, and inform business strategy
Experience collaborating across cross-functional partners to achieve business objectives
Strong communication, leadership presence, and interpersonal skills
Preferred Capabilities
Advanced degree (e.g., MBA, MPH, PharmD, PhD)
Oncology or specialty pharmaceutical experience
Experience in rare disease and/or complex, access-driven markets
Experience supporting or building commercial capabilities (e.g., sales operations, analytics, training)
Strong understanding of the full commercial ecosystem (e.g., marketing, market access, insights & analytics)
Experience leading in dynamic, fast-paced, or growth-oriented environments
Demonstrated ability to influence without authority and operate across multiple levels of the organization
Deciphera is committed to fair and equitable compensation practices. The base salary pay range for this role is $208,000 - $286,000. Actual compensation packages will depend on various factors, including, but not limited to depth of experience, education, skillset, overall performance and/or location.
Deciphera believes in providing a competitive compensation and benefits package to all employees. Our base salary is just one component of Deciphera’s competitive total rewards strategy that also includes annual performance bonus, a long-term incentive plan, full range of benefits and other incentive compensation plans (if applicable)
Benefits
- ✓Competitive salary and annual bonus.
- ✓Comprehensive benefits package including medical, dental, vision insurance, 401(k) retirement plan with company match, and more.
- ✓Generous parental leave and family planning benefits.
- ✓Outstanding culture and opportunities for personal and professional growth.
Apply Now: Join us in our mission to improve the lives of people with cancer. Apply today to become a part of our dynamic team!
EQUAL EMPLOYMENT OPPORTUNITY INFORMATION
Deciphera is committed to equal employment opportunity and values diversity. To ensure that we comply with reporting requirements, we invite you complete the confidential survey at the end of this application. Providing this information is optional.
It will not be accessible or used in the hiring process, and has no effect on your opportunity for employment. This information will also be treated confidentially. We are committed to make all hiring decisions and other employment decisions on a non-discriminatory basis.
EQUAL EMPLOYMENT OPPORTUNITY INFORMATION
Deciphera is committed to equal employment opportunity and values diversity. To ensure that we comply with reporting requirements, we invite you complete the confidential survey at the end of this application. Providing this information is optional.
It will not be accessible or used in the hiring process, and has no effect on your opportunity for employment. This information will also be treated confidentially. We are committed to make all hiring decisions and other employment decisions on a non-discriminatory basis.