About this role
Thanks for visiting our Career Page.Please review our open positions and apply to the positions that match your qualifications.About Repertoire Immune MedicinesDecoding with purpose, deploying with precision. While the immune system is the most complex and fine-tuned internal ‘medicine-producing’ engine ever created, harnessing its power to prevent and treat disease remains a new frontier. The key to the next generation of immune medicines lies in understanding the inner workings of the immune synapse – the interaction between T cells and antigen presenting cells – and an individual’s associated T cell “repertoire.”Research Associate II, Yeast DisplayWatertown, MAFull TimeIntegrated Therapeutic Engineering and DevelopmentMid LevelShareCompany OverviewRepertoire Immune Medicines is a clinical-stage biotechnology company working to unlock and direct the remarkable power of the human immune system to prevent or treat cancer, as well as autoimmune and infectious disease.
The company is founded on the belief that the repertoire of T cell receptor (TCR)-antigen codes that drive health and disease represents one of the greatest opportunities for innovation in medical science. Repertoire scientists created and developed the DECODE suite of technologies, which allow in-depth characterization of TCR-antigen pairs, and the ability to rationally design and develop novel targeted immune medicines.From its sites inWatertown, Massachusetts, and Zurich, Switzerland, Repertoire’s team of more than 80 is creating a new category of immune medicines enabled from its DECODE discovery platform. Repertoire is currently using its proprietary platform to discover novel epitopes and TCRs from patients with autoimmune diseases such as type 1 diabetes and multiple sclerosis as well as to enable development of immune oncology based therapeutics to treat solid tumors.Repertoire was founded in 2019 by Flagship Pioneering and is supported by a strong investor base.
The DECODE platform has been validated through four strategic partnerships with leading pharmaceutical companies—Bristol Myers Squibb, Genentech, Eli Lilly, and Pfizer—representing over $4.5 billion in disclosed total deal value and $185 million in upfront payments received to date.Role OverviewWe are seeking a motivated Research Associate II tojoin ourIntegrated Therapeutic Engineering and Design (ITED) teamand help advancethe discovery and development ofinnovativeprotein therapeutics.In this hands-on role, youwill play a keypartin discovering novel therapeutics through yeast display-based protein engineering.Youwill perform all techniques associated with yeast display, including culture and induction of yeast, transformation of yeast with DNA-based libraries, and phenotypic selection using fluorescence activated cell sorting (FACS) or magnetic activated cell sorting (MACS).The ideal candidateisproficient with advanced molecular biology techniques, such as PCR, primer design, golden gate cloning, and DNA preparation for sequencing,and bringsbench experience with protein display technologies, preferably yeast display.Youwillownexperimental design, implementation,anddata analysis, andshare your results with yoursupervisor and thebroaderteam in an effective and timely manner. Drive to execute, experimental rigor, and scientific curiosity are essentialto success inthis role.Stronginterpersonal, verbal, and written communication skills will enableyoutothrive withinour highlycollaborative,cross-functional teams.Key ResponsibilitiesDesign and execute experiments as a key contributor to the ITED team, under the supervision of your manager and scientific project leads.Apply recombinant protein display systems (e.g., yeast display) to protein engineering applications.Design and construct DNA libraries using molecular biology techniques (e.g., DNA isolation and purification, PCR, and transformation of yeast and/orE.coli).Enrich displayed libraries for phenotypes of interest using FACS and MACS, and analyze target binding profiles.Maintain good laboratory practices, including accurate ELN documentation, instrument and reagent validation, and adherence to lab safety policies.Present data and analysis at cross-disciplinary team meetings and build working relationships that move projects forward.Qualifications/ Desired ExperienceB.S. or M.S. in Biochemistry, Biology, Bioengineering, Immunology, or a similar field.2+ years of academic or biotech/pharma laboratory experience.Experience with protein display technologies is required. Yeast display experience is strongly preferred.Demonstrated understanding of complex molecular biology techniques is strongly preferred (e.g., PCR, primer design, DNA purification, DNA library design and construction using multiple methods (golden gate cloning, Gibson assembly, SOE), maintenance and culture of yeast and E.
Coli).Strong organizational skills, excellent attention to detail, and data analysis skills are required.Knowledge of oncology or immunology is beneficial.Experience with FlowJo, SnapGene, and JMP preferred.Desire and ability to quickly learn new lab techniques and understand the significance to program goals.Compensation and BenefitsThe base salary for this role ranges from $75,000 to $90,000 and is determined based on a candidate’s skills, experience, and internal equity. In addition to a competitive base salary, Repertoire offers a broad range of benefits designed to attract, retain, and motivate top talent, including medical, dental, vision, and life insurance, flexible time off, a 401(k)-retirement plan, and short- and long-term incentive opportunities. Compensation and benefits are based on Repertoire’s good faith estimate at the time of publication and may be updated in the future.Repertoire is committed to building an inclusive culture.
Much as the power of the immune system lies in the diversity of T and B cells, we believe our best work comes from a diverse workforce—and we are committed to pursuing that in all facets of the work experience.Repertoire is proud to be an Equal Opportunity Employer.Recruitment & Staffing Agencies:Repertoire Immune Medicines (“Repertoire”) does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Repertoire or its employees is strictly prohibited unless contacted directly by Repertoire’s internal Human Resources team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Repertoire, and Repertoire will not owe any referral or other fees with respect thereto.ShareApplyApply for this positionRequiredFirst NameLast NameEmail AddressPhoneAddressResume*We've received your resume.
Clickhereto update it.Attach resumeorPaste resumeAttach resume as .pdf, .doc, .docx, .odt, .txt, or .rtf (limit 5MB) orPaste resumePaste your resume here orAttach resume fileCover LetterWhat's your highest level of education completed?No answerGED or EquivalentHigh SchoolSome CollegeCollege - AssociatesCollege - Bachelor of ArtsCollege - Bachelor of Fine ArtsCollege - Bachelor of ScienceCollege - Master of ArtsCollege - Master of ScienceCollege - Master of Fine ArtsCollege - Master of Business AdministrationCollege - DoctorateMedical DoctorOtherLinkedIn Profile URL:Desired salaryEarliest start date?Are you authorized to work in the United States?-- No answer --YesNoWill you now or in the future require sponsorship for employment visa status? (e.g., H-1B visa status?)-- No answer --YesNoIf you were referred by a current Repertoire employee, please provide the employee's name here:We are only evaluating candidates who currently reside in reasonable commuting distance to our office in Watertown, MA. Does your current location meet this requirement?YesNoHuman Check*Submit Application