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Senior Radioanalytical Development Scientist

Ratio Therapeutics, Inc.

$145k – $165k/yrPosted Jul 8, 2026

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Senior Analytical Development Scientist

CMC - Boston, Massachusetts

About Ratio Therapeutics

Ratio Therapeutics is committed to improving and extending the lives of cancer patients without sacrificing their quality of life. We are a team of passionate scientists, engineers, and business professionals dedicated to advancing the field of targeted radioligand therapy. To accomplish this, we utilize our proprietary TRILLIUM™ and MACROPA™ platforms: TRILLIUM™ allows fine-tuning of radioligand pharmacokinetics thereby enhancing the therapeutic index, while MACROPA™ simplifies the manufacturing process for the alpha-emitting isotope, actinium-225. These enabling platform technologies have resulted in an emergent pipeline of novel therapeutic candidates. We are looking for talented, dedicated, and creative individuals eager to help us advance these technologies from discovery research through clinical development. Join us in our quest to become the leading innovator in radioligand therapy and improve the lives of cancer patients and their families.

About the Position

Ratio is seeking a Senior Scientist, Analytical Development to join our growing team of scientists. In this role, the successful candidate will be responsible for analytical method development to support GMP method development and technology transfer. The ideal candidate has a track-record of successful GMP technology development, enjoys working in a collaborative and fast-paced environment, and will seek to maintain trustworthy relationships with interdisciplinary teams at partner organizations.

Key Responsibilities

Independently develop and optimize analytical quality control methods (such as HPLC, TLC, LC-MS and GC) to support advancement of Ratio’s lead compounds.

Lead the transition of early-phase analytical method development to methods appropriate for technology transfer. Lead the transition of early phase methods into GMP/GLP appropriate QC methods.

Design and execute phase-appropriate analytical strategies, including method qualification/verification/validation suitable for tech transfer and regulatory submissions.

Serve as a main point of contact for analytical method technology transfer to CDMO and Ratio Manufacturing sites. Occasional business travel may be required (approximately 10%, Contiguous US) to facilitate technology transfer and troubleshooting activities at CDMO and internal sites.

Author, review, and approve analytical documentation (such as protocols, methods, reports and relevant sections of IND/IMPD sections and other regulatory filings).

Lead analytical method training for quality control personnel in analytical techniques, data interpretation and best practices to ensure consistent execution and data integrity.

Support OOS/OOT and deviation investigations, identify root causes and implement corrective and preventive actions related to analytical methods and instrumentation.

Ensure compliance with GMP, GLP, and data integrity requirements, contributing to inspection readiness and continuous improvement of processes and workflows.

Qualifications and Requirements

PhD in chemistry, pharmaceutical sciences, or a related life sciences field with 5+ years of relevant industry and/or academic experience; MSc with 10+ years or BS with 12+ years of relevant experience

Prior experience with radioactive materials such as radiopharmaceuticals and medical isotopes is required.

Demonstrated experience in radiopharmaceutical analytical quality control method development (e.g., HPLC, MS, TLC, etc.) and advanced theoretical understanding of separation science.

Detailed working knowledge of cGMP and ICH/FDA guidelines with a strong interest in advancing knowledge in this area.

Experience with project management (experience managing external CROs or CDMOs is an asset).

Proven aptitude in technical and regulatory writing.

Ability to work effectively in a cross functional team environment and to influence without direct authority.

High attention to detail and a quality and data-integrity oriented mindset.

Open-minded and self-motivating attitude.

Computer skills (Microsoft Office suite, chromatography software/LIMS, etc.).

Experience in pharmaceutical manufacturing process research and development is an asset.

Ready and able to work in a laboratory environment for up to 8 hours a day and able to lift up to 30 lbs.

The annual base salary for this role is expected to range between $145,000 and $165,000. This range is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. The actual base salary offered will depend on a variety of factors, including qualifications, work experience, skills, level of education attained, certifications or other professional licenses held, the location in which the applicant lives and/or from which they will be performing the job, and other job-related factors permitted by law.

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Location

Boston, Massachusetts

Department

CMC

Employment Type

Full-Time

Minimum Experience

Experienced

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