About this role
Scientist II Job Locations US-CA-San Diego Job ID 2026-14180 Overview HD Biosciences Inc. , a WuXi AppTec company, offers biology-focused preclinical drug discovery services to biotech and pharmaceutical clients. We offer our clients comprehensive service platforms around target validation, plate-based pharmacology, hit identification and lead discovery, in vivo pharmacology, as well as other research and development services. We are seeking an initiative-taking and skilled scientist to join our fast-growing bioanalysis team.
The position will independently design, execute, trouble shoot and deliver the projects with LC-MS (liquid chromatography – mass spectrometry), prioritizing large molecules such as biologics, peptides, ADCs (antibody drug conjugates), LNPs (lipid nanoparticles), and oligos, and including small molecule modalities when necessary. Responsibilities This is a laboratory-based role. Hands-on bench work is required Provides scientific and operational support for bioanalysis group Actively contributes and applies expertise and knowledge to collaborations with partners in the design and execution of related studies Contributes to project proposal preparation Leads ongoing projects to meet expected timelines Contributes for new capability implementation and team building Contributes to the overall operations and to the achievement of departmental goals Communicates with clients for designing, analysis, reporting and recording activities Performs job specific tasks in compliance with applicable Regulations, International Standards, WuXi AppTec Policies and Standard Operating Procedures Qualifications PhD with 4+ years of relevant industry experience, MS with 7+ years of experience in Bioanalysis and Mass Spectrometry, and/or related field Strong scientific knowledge and hands-on technical expertise in LC-MS-based bioanalysis and drug discovery workflows.
Industry experience in a CRO environment is highly desirable Demonstrated experience supporting ADC, biologic, LNP, small-molecule and/or oligonucleotide programs is strongly preferred. Technical expertise: Solid understanding of qualitative and quantitative LC-MS workflows for ADCs, LNPs, peptides/proteins, biologics, small molecules, including associated sample preparation techniques Strong competency with a broad range of LC-MS instrumentation, including triple quadrupole (QQQ), QTOF, and Orbitrap platforms Hands-on experience with LC-MS method development, optimization, troubleshooting Experience developing and executing ADC bioanalytical assays, including characterization and/or quantification of ADCs, antibody/antibody-drug conjugate components, payloads, metabolites, and relevant catabolites Experience with LNP analysis by LC-MS, including characterization and/or quantitative analysis of LNP-associated components, lipid components, payloads, or related analytes Experience with DMPK and bioanalysis, including quantitative analysis of drug candidates and metabolites in biological matrices Strong experience with sample preparation from tissues, cells, plasma/serum, and other biofluids Proficiency with relevant data analysis and bioinformatics software, such as Skyline Prior experience with in vitro assays and/or ex vivo pharmacology studies supporting drug discovery programs is a plus Willingness and ability to lead or support studies beyond the LC-MS area, including cross-functional projects and drug discovery activities as needed Knowledge / Skills / Abilities: Demonstrated time management and multi-tasking skills, ability to effectively prioritize workload and manage changes in direction Demonstrated ability for attention to details and concern for impact Effective communication skills with the ability to give and receive feedback, both verbally and in writing Ability to work in a team environment and independently as required. Ability to work in a fast-paced environment Well organized and adaptable to changes Computer skills: knowledge of internet research, MS Word, Excel, Outlook, and PowerPoint.
Ability to learn instrument and data analysis software Physical Requirements: · Must be able to work in an office environment with minimal noise conditions · Must be able to work in a lab setting with exposure to Animals/biohazards /Chemicals (List specific Chemicals) · Must not have animal allergies to applicable species in this facility · Must be able to work in environment with variable noise levels · Ability to stand/Sit/walk for long periods of time · Ability to Lift 10 lbs routinely · Ability to push/pull 10 lbs. routinely/often/occasionally · Clarity of vision · Ability to identify and distinguish colors · Must be able to perform activities with repetitive motions · Ability to climb ladders/stairs/scaffolding · Ability to work in variable temperatures high to freezing · Inside/outside working conditions Anticipated base pay range: $82,731 to $107,132 An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability This job description does not state or imply that the above are the only duties and responsibilities assigned to this position. Employees holding this position will be required to perform any other job-related duties as requested by Management.
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